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Assay Detail

CHEMBL1777060

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human purified PMM2
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Phosphomannomutase 2 (CHEMBL1741162)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.
Dahl R, Bravo Y, Sharma V, Ichikawa M, Dhanya RP, Hedrick M, Brown B, Rascon J, Vicchiarelli M, Mangravita-Novo A, Yang L, Stonich D, Su Y, Smith LH, Sergienko E, Freeze HH, Cosford ND.
J Med Chem (2011) 54 : 3661 -3668
PubMed 21539312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 4.86 5.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1725120 1 5.14
CHEMBL1314602 1 5.04
CHEMBL1706034 1 4.89
CHEMBL1714438 1 4.88
CHEMBL1708710 1 4.86
CHEMBL1369613 1 4.81
CHEMBL1449845 1 4.75
CHEMBL1601716 1 4.50
CHEMBL1702821 1 -
CHEMBL1700715 1 -
CHEMBL1336959 1 -
CHEMBL1712882 1 -
CHEMBL1698123 1 -
CHEMBL98386 1 -
CHEMBL1720939 1 -
CHEMBL1708335 1 -
CHEMBL1706897 1 -
CHEMBL45152 1 -
CHEMBL1711919 1 -
CHEMBL1406130 1 -
CHEMBL1553163 1 -
CHEMBL1701599 1 -
CHEMBL1701846 1 -
CHEMBL1715729 1 -
CHEMBL1310318 1 -
CHEMBL1720377 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1725120 IC50 = 7300.0 nM 5.14
CHEMBL1314602 IC50 = 9100.0 nM 5.04
CHEMBL1706034 IC50 = 12900.0 nM 4.89
CHEMBL1714438 IC50 = 13300.0 nM 4.88
CHEMBL1708710 IC50 = 13900.0 nM 4.86
CHEMBL1369613 IC50 = 15400.0 nM 4.81
CHEMBL1449845 IC50 = 17900.0 nM 4.75
CHEMBL1601716 IC50 = 31300.0 nM 4.50
CHEMBL1702821 IC50 > 20000.0 nM -
CHEMBL1700715 IC50 > 20000.0 nM -
CHEMBL1336959 IC50 > 20000.0 nM -
CHEMBL1712882 IC50 > 20000.0 nM -
CHEMBL1698123 IC50 > 20000.0 nM -
CHEMBL98386 IC50 > 20000.0 nM -
CHEMBL1720939 IC50 > 20000.0 nM -
CHEMBL1708335 IC50 > 20000.0 nM -
CHEMBL1706897 IC50 > 20000.0 nM -
CHEMBL45152 IC50 > 20000.0 nM -
CHEMBL1711919 IC50 > 10000.0 nM -
CHEMBL1406130 IC50 > 80000.0 nM -
CHEMBL1553163 IC50 > 80000.0 nM -
CHEMBL1701599 IC50 > 20000.0 nM -
CHEMBL1701846 IC50 > 20000.0 nM -
CHEMBL1715729 IC50 > 20000.0 nM -
CHEMBL1310318 IC50 > 20000.0 nM -
CHEMBL1720377 IC50 > 20000.0 nM -