Assay Detail
Functional
CHEMBL1777583
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Antiviral activity against Cowpox virus (Brighton Red) infected in human HFF cells after 3 days by plaque reduction assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cowpox virus (Brighton Red) |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774184 | — | — | 1 | 8.00 |
| CHEMBL472584 | — | — | 1 | 7.70 |
| CHEMBL1774182 | — | — | 1 | 7.70 |
| CHEMBL1652472 | — | — | 1 | 7.40 |
| CHEMBL1774183 | — | — | 1 | 7.05 |
| CHEMBL1774177 | — | — | 1 | 7.00 |
| CHEMBL203321 | BRINCIDOFOVIR | 4.0 | 1 | 6.70 |
| CHEMBL1774179 | — | — | 1 | 6.52 |
| CHEMBL1774180 | — | — | 1 | 6.52 |
| CHEMBL1774178 | — | — | 1 | 6.30 |
| CHEMBL1774181 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774184 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL472584 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1774182 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1652472 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1774183 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1774177 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL203321 | BRINCIDOFOVIR | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1774179 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1774180 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1774178 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1774181 | — | EC50 | = | 800.0 | nM | 6.10 |