Assay Detail
Functional
CHEMBL1781268
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.86 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216973 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.66 |
| CHEMBL3216515 | — | — | 1 | 8.52 |
| CHEMBL3216972 | — | — | 1 | 8.40 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.35 |
| CHEMBL3216091 | — | — | 1 | 8.22 |
| CHEMBL1232057 | — | — | 1 | 8.11 |
| CHEMBL3217179 | — | — | 1 | 8.05 |
| CHEMBL48217 | DAPI | — | 1 | 7.75 |
| CHEMBL3216750 | — | — | 1 | 6.67 |
| CHEMBL1780243 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216973 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3216515 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3216972 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3216091 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1232057 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3217179 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL48217 | DAPI | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3216750 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL1780243 | — | IC50 | = | 8723.0 | nM | 5.06 |