Assay Detail
Functional
CHEMBL1781691
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Antiprotozoan activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trichomonas vaginalis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.04 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 7.17 |
| CHEMBL1545 | TIZOXANIDE | -1.0 | 1 | 6.68 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 6.54 |
| CHEMBL1779947 | — | — | 1 | 6.08 |
| CHEMBL1779948 | — | — | 1 | 5.67 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.42 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1401 | NITAZOXANIDE | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1545 | TIZOXANIDE | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1779947 | — | IC50 | = | 842.0 | nM | 6.08 |
| CHEMBL1779948 | — | IC50 | = | 2147.0 | nM | 5.67 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3815.0 | nM | 5.42 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 18620.0 | nM | 4.73 |