Assay Detail
Binding
CHEMBL1781815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat Oat1 expressed in Xenopus oocytes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 6 (CHEMBL1777665) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.67 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL783 | NATEGLINIDE | 4.0 | 1 | 5.04 |
| CHEMBL586 | SALICYLURIC ACID | — | 1 | 4.96 |
| CHEMBL498 | CHLORPROPAMIDE | 4.0 | 1 | 4.40 |
| CHEMBL782 | TOLBUTAMIDE | 4.0 | 1 | 4.26 |
| CHEMBL1778338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL783 | NATEGLINIDE | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL586 | SALICYLURIC ACID | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL498 | CHLORPROPAMIDE | Ki | = | 39500.0 | nM | 4.40 |
| CHEMBL782 | TOLBUTAMIDE | Ki | = | 55500.0 | nM | 4.26 |
| CHEMBL1778338 | — | Ki | = | 1100000.0 | nM | - |