Compound Detail
CHEMBL586
SALICYLURIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL586 |
| Name | SALICYLURIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ONJSZLXSECQROL-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
11
Publications
1
Known Names
Molecular Properties
195.2
MW (Da)
0.21
ALogP
3
HBA
3
HBD
86.6
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 4.96
IC50 1 meas. best 4.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 22 member 6 CHEMBL1777665 | Ki | 4.96 | 4.96 | 11000.0 | 2 |
| Solute carrier family 22 member 6 CHEMBL1641347 | IC50 | 4.57 | 4.57 | 27000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 6 | Ki | = | 11000.0 | nM | 4.96 | Inhibition of rat Oat1 expressed in Xenopus oocytes | 21571536 |
| Solute carrier family 22 member 6 | Ki | = | 11000.0 | nM | 4.96 | TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes | 10220563 |
| Solute carrier family 22 member 6 | IC50 | = | 27000.0 | nM | 4.57 | TP_TRANSPORTER: inhibition of PAH uptake in OAT-expressing OK cells | 11815391 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9083481 | 10.1021/jm960754h | Human immunodeficiency virus type 1 integrase | 4 |
| 18952446 | 10.1016/j.bmc.2008.10.013 | Peptidylglycine alpha-amidating monooxygenase | 4 |
| 9544216 | 10.1021/jm970811m | ADMET | 1 |
| 9544216 | 10.1021/jm970811m | NON-PROTEIN TARGET | 1 |
| 20822901 | 10.1016/j.bmcl.2010.08.032 | Prolyl hydroxylase EGLN2 | 1 |
| 21571536 | 10.1016/j.bmc.2011.04.045 | Solute carrier family 22 member 6 | 1 |
| 11815391 | 10.1038/sj.bjp.0704482 | Solute carrier family 22 member 6 | 1 |
| 10220563 | - | Solute carrier family 22 member 6 | 1 |
| 26204233 | 10.1021/acs.jmedchem.5b00536 | Intestine | 1 |
| 26204233 | 10.1021/acs.jmedchem.5b00536 | ADMET | 1 |
| 26784936 | 10.1021/acs.jmedchem.5b01961 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine