Assay Detail
Functional
CHEMBL2076050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 6 (CHEMBL1777665) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.98 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154 | NAPROXEN | 4.0 | 1 | 5.70 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.46 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.00 |
| CHEMBL586 | SALICYLURIC ACID | — | 1 | 4.96 |
| CHEMBL1228 | OXYPHENBUTAZONE ANHYDROUS | 4.0 | 1 | 4.50 |
| CHEMBL527 | PIROXICAM | 4.0 | 1 | 4.28 |
| CHEMBL112 | ACETAMINOPHEN | 4.0 | 1 | - |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
| CHEMBL16073 | PHENACETIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154 | NAPROXEN | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL521 | IBUPROFEN | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL6 | INDOMETHACIN | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL586 | SALICYLURIC ACID | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1228 | OXYPHENBUTAZONE ANHYDROUS | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL527 | PIROXICAM | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL112 | ACETAMINOPHEN | Ki | = | 2099000.0 | nM | - |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 341000.0 | nM | - |
| CHEMBL25 | ASPIRIN | Ki | = | 428000.0 | nM | - |
| CHEMBL16073 | PHENACETIN | Ki | = | 488000.0 | nM | - |