Assay Detail
Binding
CHEMBL1785219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DSLET from delta opioid receptor in rat brain membranes after 2 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.60 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782140 | — | — | 1 | 9.22 |
| CHEMBL1782141 | — | — | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782140 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1782141 | — | Ki | = | 10.4 | nM | 7.98 |