Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1785239

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of p38alpha
ChEMBL ↗
88
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 14 (CHEMBL260) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Molecular modeling studies of phenoxypyrimidinyl imidazoles as p38 kinase inhibitors using QSAR and docking.
Ravindra GK, Achaiah G, Sastry GN.
Eur J Med Chem (2008) 43 : 830 -838
PubMed 17706839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 88 7.17 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL13850 — — 2 8.22
CHEMBL273432 — — 2 8.18
CHEMBL428877 — — 2 8.13
CHEMBL276576 — — 2 7.97
CHEMBL14329 — — 2 7.89
CHEMBL14763 — — 2 7.85
CHEMBL13836 — — 2 7.82
CHEMBL14212 — — 2 7.82
CHEMBL275798 — — 2 7.72
CHEMBL14682 — — 2 7.72
CHEMBL14300 — — 2 7.70
CHEMBL13880 — — 2 7.67
CHEMBL273611 — — 2 7.64
CHEMBL417804 — — 2 7.60
CHEMBL277521 — — 2 7.46
CHEMBL417255 — — 2 7.39
CHEMBL417079 — — 2 7.39
CHEMBL268946 — — 2 7.25
CHEMBL14187 — — 2 7.22
CHEMBL14697 — — 2 7.12
CHEMBL275200 — — 2 7.10
CHEMBL14233 — — 2 7.09
CHEMBL1784928 — — 2 7.07
CHEMBL275724 — — 2 7.05
CHEMBL14014 — — 2 7.02
CHEMBL275168 — — 2 6.94
CHEMBL273525 — — 2 6.92
CHEMBL13868 — — 2 6.89
CHEMBL275666 — — 2 6.88
CHEMBL1785002 — — 2 6.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL13850 — IC50 = 6.0 nM 8.22
CHEMBL13850 — IC50 = 6.026 nM 8.22
CHEMBL273432 — IC50 = 6.6 nM 8.18
CHEMBL273432 — IC50 = 6.607 nM 8.18
CHEMBL428877 — IC50 = 7.4 nM 8.13
CHEMBL428877 — IC50 = 7.413 nM 8.13
CHEMBL276576 — IC50 = 10.7 nM 7.97
CHEMBL276576 — IC50 = 10.72 nM 7.97
CHEMBL14329 — IC50 = 12.88 nM 7.89
CHEMBL14329 — IC50 = 13.0 nM 7.89
CHEMBL14763 — IC50 = 14.13 nM 7.85
CHEMBL14763 — IC50 = 14.0 nM 7.85
CHEMBL13836 — IC50 = 15.0 nM 7.82
CHEMBL14212 — IC50 = 15.14 nM 7.82
CHEMBL13836 — IC50 = 15.14 nM 7.82
CHEMBL14212 — IC50 = 15.2 nM 7.82
CHEMBL275798 — IC50 = 19.2 nM 7.72
CHEMBL14682 — IC50 = 19.0 nM 7.72
CHEMBL14682 — IC50 = 19.05 nM 7.72
CHEMBL275798 — IC50 = 19.05 nM 7.72
CHEMBL14300 — IC50 = 20.0 nM 7.70
CHEMBL14300 — IC50 = 19.95 nM 7.70
CHEMBL13880 — IC50 = 21.6 nM 7.67
CHEMBL13880 — IC50 = 21.88 nM 7.66
CHEMBL273611 — IC50 = 22.91 nM 7.64
CHEMBL273611 — IC50 = 23.0 nM 7.64
CHEMBL417804 — IC50 = 25.12 nM 7.60
CHEMBL417804 — IC50 = 25.0 nM 7.60
CHEMBL277521 — IC50 = 34.3 nM 7.46
CHEMBL277521 — IC50 = 34.67 nM 7.46
CHEMBL417255 — IC50 = 41.0 nM 7.39
CHEMBL417079 — IC50 = 41.0 nM 7.39
CHEMBL417079 — IC50 = 40.74 nM 7.39
CHEMBL417255 — IC50 = 40.74 nM 7.39
CHEMBL268946 — IC50 = 56.0 nM 7.25
CHEMBL268946 — IC50 = 56.23 nM 7.25
CHEMBL14187 — IC50 = 60.26 nM 7.22
CHEMBL14187 — IC50 = 60.0 nM 7.22
CHEMBL14697 — IC50 = 75.0 nM 7.12
CHEMBL14697 — IC50 = 75.86 nM 7.12
CHEMBL275200 — IC50 = 79.0 nM 7.10
CHEMBL275200 — IC50 = 79.43 nM 7.10
CHEMBL14233 — IC50 = 81.28 nM 7.09
CHEMBL14233 — IC50 = 82.0 nM 7.09
CHEMBL1784928 — IC50 = 85.4 nM 7.07
CHEMBL1784928 — IC50 = 85.11 nM 7.07
CHEMBL275724 — IC50 = 89.7 nM 7.05
CHEMBL275724 — IC50 = 89.13 nM 7.05
CHEMBL14014 — IC50 = 95.0 nM 7.02
CHEMBL14014 — IC50 = 95.5 nM 7.02