Compound Detail
CHEMBL13836
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Basic Information
| ChEMBL ID | CHEMBL13836 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VHEPATGINYKFPP-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
429.5
MW (Da)
5.17
ALogP
6
HBA
1
HBD
64.9
PSA (Ų)
0.47
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 7.82 | 7.82 | 15.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 15.0 | nM | 7.82 | Inhibitory concentration against mitogen-activated protein kinase p38 alpha | 11354358 |
| Mitogen-activated protein kinase 14 | IC50 | = | 15.14 | nM | 7.82 | Inhibition of p38alpha | 17706839 |
| Mitogen-activated protein kinase 14 | IC50 | = | 15.0 | nM | 7.82 | Inhibition of p38alpha | 17706839 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17706839 | 10.1016/j.ejmech.2007.06.009 | Mitogen-activated protein kinase 14 | 2 |
| 11354358 | 10.1016/s0960-894x(01)00163-9 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine