Assay Detail
Binding
CHEMBL874040
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Inhibitory concentration against mitogen-activated protein kinase p38 alpha
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenoxypyrimidine inhibitors of p38alpha kinase: synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 7.14 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13850 | — | — | 1 | 8.22 |
| CHEMBL273432 | — | — | 1 | 8.18 |
| CHEMBL428877 | — | — | 1 | 8.13 |
| CHEMBL276576 | — | — | 1 | 7.97 |
| CHEMBL14329 | — | — | 1 | 7.89 |
| CHEMBL14763 | — | — | 1 | 7.85 |
| CHEMBL14212 | — | — | 1 | 7.82 |
| CHEMBL13836 | — | — | 1 | 7.82 |
| CHEMBL14478 | — | — | 1 | 7.80 |
| CHEMBL14300 | — | — | 1 | 7.73 |
| CHEMBL275798 | — | — | 1 | 7.72 |
| CHEMBL14682 | — | — | 1 | 7.72 |
| CHEMBL274064 | SB-220025 | — | 1 | 7.70 |
| CHEMBL14125 | — | — | 1 | 7.70 |
| CHEMBL13880 | — | — | 1 | 7.67 |
| CHEMBL273611 | — | — | 1 | 7.64 |
| CHEMBL417804 | — | — | 1 | 7.60 |
| CHEMBL277521 | — | — | 1 | 7.46 |
| CHEMBL417079 | — | — | 1 | 7.39 |
| CHEMBL417255 | — | — | 1 | 7.39 |
| CHEMBL10 | SB-203580 | — | 1 | 7.32 |
| CHEMBL268946 | — | — | 1 | 7.25 |
| CHEMBL279416 | VK-19911 | — | 1 | 7.22 |
| CHEMBL14187 | — | — | 1 | 7.22 |
| CHEMBL14697 | — | — | 1 | 7.12 |
| CHEMBL275200 | — | — | 1 | 7.10 |
| CHEMBL14233 | — | — | 1 | 7.09 |
| CHEMBL14026 | — | — | 1 | 7.07 |
| CHEMBL275724 | — | — | 1 | 7.05 |
| CHEMBL14014 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13850 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL273432 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL428877 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL276576 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL14329 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL14763 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL14212 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL13836 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL14478 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL14300 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL275798 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL14682 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL274064 | SB-220025 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL14125 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL13880 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL273611 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL417804 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL277521 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL417079 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL417255 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL10 | SB-203580 | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL268946 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL279416 | VK-19911 | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL14187 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL14697 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL275200 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL14233 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL14026 | — | IC50 | = | 85.4 | nM | 7.07 |
| CHEMBL275724 | — | IC50 | = | 89.7 | nM | 7.05 |
| CHEMBL14014 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL275168 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL273525 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL13868 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL275666 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL14565 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL278498 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL275271 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL13950 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL13972 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL276094 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL14339 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL264227 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL279587 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL269450 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL14318 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL14170 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL14228 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL13830 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL276014 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL274863 | — | IC50 | = | 480.0 | nM | 6.32 |