Assay Detail
Binding
CHEMBL1785676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-alpha-Conotoxin MII from alpha6beta2* nAChR in mouse olfactory tubercles, striatum and superior coliculus
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Olfactory tubercle |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-6/beta-2 (CHEMBL3885611) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.02 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217150 | — | — | 1 | 8.96 |
| CHEMBL1783886 | — | — | 1 | 8.10 |
| CHEMBL1783888 | — | — | 1 | 7.77 |
| CHEMBL3215819 | — | — | 1 | 7.26 |
| CHEMBL1783881 | — | — | 1 | 7.07 |
| CHEMBL1783882 | — | — | 1 | 6.94 |
| CHEMBL1783883 | — | — | 1 | 6.74 |
| CHEMBL1782074 | — | — | 1 | 6.62 |
| CHEMBL1783884 | — | — | 1 | 6.49 |
| CHEMBL1783878 | — | — | 1 | 6.47 |
| CHEMBL1783880 | — | — | 1 | 5.97 |
| CHEMBL1783879 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217150 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1783886 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1783888 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3215819 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL1783881 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL1783882 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL1783883 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL1782074 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL1783884 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL1783878 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL1783880 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL1783879 | — | Ki | = | 1550.0 | nM | 5.81 |