Assay Detail
Binding
CHEMBL1785679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at alpha6alpha4beta3beta2 nAChR in mouse striatal synaptosomes assessed as alpha-conotoxic MII-resistant DA release
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-4/alpha-6/beta-2/beta-3 (CHEMBL3885610) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.42 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217150 | — | — | 1 | 8.15 |
| CHEMBL1783886 | — | — | 1 | 7.05 |
| CHEMBL1783888 | — | — | 1 | 7.00 |
| CHEMBL3215819 | — | — | 1 | 6.70 |
| CHEMBL1783884 | — | — | 1 | 6.28 |
| CHEMBL1782074 | — | — | 1 | 6.16 |
| CHEMBL1783883 | — | — | 1 | 6.10 |
| CHEMBL1783878 | — | — | 1 | 5.92 |
| CHEMBL1783880 | — | — | 1 | 4.43 |
| CHEMBL1783879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217150 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1783886 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1783888 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3215819 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1783884 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1782074 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1783883 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1783878 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1783880 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1783879 | — | EC50 | - | — | - |