Assay Detail
ADMET
CHEMBL1785940
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Inhibition of CYP2C9 after 30 mins by luminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Toluidinesulfonamide hypoxia-induced factor 1 inhibitors: alleviating drug-drug interactions through use of PubChem data and comparative molecular field analysis guided synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.33 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1319809 | — | — | 1 | 6.60 |
| CHEMBL1784702 | — | — | 1 | 5.80 |
| CHEMBL1450745 | — | — | 1 | 5.60 |
| CHEMBL1386228 | — | — | 1 | 5.40 |
| CHEMBL1784701 | — | — | 1 | 5.40 |
| CHEMBL1784699 | — | — | 1 | 4.80 |
| CHEMBL1784700 | — | — | 1 | 4.60 |
| CHEMBL1784698 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1319809 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL1784702 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL1450745 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL1386228 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL1784701 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL1784699 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL1784700 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL1784698 | — | EC50 | = | 39810.72 | nM | 4.40 |