Assay Detail
Binding
CHEMBL1786302
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Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substrates
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of selective PDE4B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.70 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782307 | — | — | 1 | 8.17 |
| CHEMBL1782308 | — | — | 1 | 7.82 |
| CHEMBL1782306 | — | — | 1 | 7.82 |
| CHEMBL1782305 | — | — | 1 | 7.72 |
| CHEMBL1782304 | — | — | 1 | 7.47 |
| CHEMBL1784118 | — | — | 1 | 7.47 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.43 |
| CHEMBL1782290 | — | — | 1 | 7.17 |
| CHEMBL1782298 | — | — | 1 | 7.11 |
| CHEMBL1784114 | — | — | 1 | 6.92 |
| CHEMBL1782289 | — | — | 1 | 6.92 |
| CHEMBL1784109 | — | — | 1 | 6.85 |
| CHEMBL1782297 | — | — | 1 | 6.82 |
| CHEMBL1784107 | — | — | 1 | 6.72 |
| CHEMBL1782303 | — | — | 1 | 6.72 |
| CHEMBL1782295 | — | — | 1 | 6.68 |
| CHEMBL1782294 | — | — | 1 | 6.66 |
| CHEMBL1782296 | — | — | 1 | 6.66 |
| CHEMBL1784116 | — | — | 1 | 6.52 |
| CHEMBL1782286 | — | — | 1 | 6.50 |
| CHEMBL1784108 | — | — | 1 | 6.37 |
| CHEMBL1784117 | — | — | 1 | 6.27 |
| CHEMBL1782302 | — | — | 1 | 6.22 |
| CHEMBL1782288 | — | — | 1 | 6.16 |
| CHEMBL1782293 | — | — | 1 | 6.07 |
| CHEMBL1782300 | — | — | 1 | 6.03 |
| CHEMBL1782301 | — | — | 1 | 5.92 |
| CHEMBL1784110 | — | — | 1 | 5.89 |
| CHEMBL1782299 | — | — | 1 | 5.75 |
| CHEMBL1782291 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782307 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1782308 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1782306 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1782305 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1782304 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1784118 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1782290 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1782298 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1782289 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1784114 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1784109 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1782297 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1784107 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1782303 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1782295 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1782294 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1782296 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1784116 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1782286 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1784108 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1784117 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1782302 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1782288 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1782293 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1782300 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1782301 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1784110 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1782299 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1782291 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1782292 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1784115 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1784113 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1784112 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1784111 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1782287 | — | IC50 | > | 1000.0 | nM | - |