Compound Detail
CHEMBL1782286
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Basic Information
| ChEMBL ID | CHEMBL1782286 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NPNUFIXGALUZRZ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
379.5
MW (Da)
4.92
ALogP
5
HBA
2
HBD
75.1
PSA (Ų)
0.57
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 6.5 | 6.5 | 320.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 5.06 | 5.06 | 8800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 320.0 | nM | 6.5 | Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substra... | 19447034 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 8800.0 | nM | 5.06 | Inhibition of human PDE4D3 incubated for 10 mins using cAMP and [3H]cAMP substra... | 19447034 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19447034 | 10.1016/j.bmcl.2009.04.121 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 19447034 | 10.1016/j.bmcl.2009.04.121 | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 19447034 | 10.1016/j.bmcl.2009.04.121 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine