Assay Detail
Functional
CHEMBL1786368
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human BxPC3 cells expressing FGFR after 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Acenaphtho[1,2-b]pyrrole-based selective fibroblast growth factor receptors 1 (FGFR1) inhibitors: design, synthesis, and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.92 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1784727 | — | — | 1 | 5.60 |
| CHEMBL1784738 | — | — | 1 | 5.60 |
| CHEMBL1784725 | — | — | 1 | 5.33 |
| CHEMBL1784734 | — | — | 1 | 5.32 |
| CHEMBL1784726 | — | — | 1 | 5.24 |
| CHEMBL1784735 | — | — | 1 | 5.00 |
| CHEMBL1784737 | — | — | 1 | 4.89 |
| CHEMBL1784740 | — | — | 1 | 4.86 |
| CHEMBL1784736 | — | — | 1 | 4.63 |
| CHEMBL1784718 | — | — | 1 | 4.60 |
| CHEMBL1784742 | — | — | 1 | 4.42 |
| CHEMBL1784741 | — | — | 1 | 4.27 |
| CHEMBL1784739 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1784727 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1784738 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1784725 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1784734 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1784726 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1784735 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1784737 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL1784740 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL1784736 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL1784718 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1784742 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL1784741 | — | IC50 | = | 54100.0 | nM | 4.27 |
| CHEMBL1784739 | — | IC50 | = | 56300.0 | nM | 4.25 |