Compound Detail
CHEMBL1784734
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Basic Information
| ChEMBL ID | CHEMBL1784734 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CGJSZRHNKLUWIE-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
289.3
MW (Da)
2.67
ALogP
3
HBA
0
HBD
55.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.72 | 7.72 | 19.0 | 1 |
| T-24 CHEMBL614774 | IC50 | 5.41 | 5.41 | 3900.0 | 1 |
| BXPC-3 CHEMBL614530 | IC50 | 5.32 | 5.32 | 4800.0 | 1 |
| WI-38 CHEMBL614391 | IC50 | 4.69 | 4.69 | 20600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 19.0 | nM | 7.72 | Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA | 21517068 |
| T-24 | IC50 | = | 3900.0 | nM | 5.41 | Antiproliferative activity against human T24 cells expressing FGFR after 72 hrs ... | 21517068 |
| BXPC-3 | IC50 | = | 4800.0 | nM | 5.32 | Antiproliferative activity against human BxPC3 cells expressing FGFR after 72 hr... | 21517068 |
| WI-38 | IC50 | = | 20600.0 | nM | 4.69 | Antiproliferative activity against human WI38 cells expressing FGFR after 72 hrs... | 21517068 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21517068 | 10.1021/jm200258t | Fibroblast growth factor receptor 1 | 3 |
| 21517068 | 10.1021/jm200258t | T-24 | 1 |
| 21517068 | 10.1021/jm200258t | WI-38 | 1 |
| 21517068 | 10.1021/jm200258t | BXPC-3 | 1 |
Data from ChEMBL 36 via Core Engine