Compound Detail
CHEMBL1784740
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Basic Information
| ChEMBL ID | CHEMBL1784740 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DDYACYWLURAUEJ-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
437.5
MW (Da)
4.43
ALogP
6
HBA
0
HBD
72.8
PSA (Ų)
0.26
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.24 | 6.24 | 577.0 | 1 |
| BXPC-3 CHEMBL614530 | IC50 | 4.86 | 4.86 | 13700.0 | 1 |
| T-24 CHEMBL614774 | IC50 | 4.14 | 4.14 | 71800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 577.0 | nM | 6.24 | Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA | 21517068 |
| BXPC-3 | IC50 | = | 13700.0 | nM | 4.86 | Antiproliferative activity against human BxPC3 cells expressing FGFR after 72 hr... | 21517068 |
| T-24 | IC50 | = | 71800.0 | nM | 4.14 | Antiproliferative activity against human T24 cells expressing FGFR after 72 hrs ... | 21517068 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21517068 | 10.1021/jm200258t | Fibroblast growth factor receptor 1 | 1 |
| 21517068 | 10.1021/jm200258t | T-24 | 1 |
| 21517068 | 10.1021/jm200258t | WI-38 | 1 |
| 21517068 | 10.1021/jm200258t | BXPC-3 | 1 |
Data from ChEMBL 36 via Core Engine