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Assay Detail

CHEMBL1794581

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Dose response for HTS for Beta-2AR agonists via FAP method from CP1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID492947, AID504448]
ChEMBL ↗
241
Total Activities
230
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Beta-2 adrenergic receptor (CHEMBL210) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 241 6.27 8.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1082607 SALMETEROL XINAFOATE 4.0 1 8.35
CHEMBL1562838 — — 1 8.33
CHEMBL1528906 — — 1 8.11
CHEMBL1444240 — — 1 8.09
CHEMBL1735137 — — 1 7.97
CHEMBL1458579 — — 1 7.94
CHEMBL1339094 — — 1 7.88
CHEMBL1484690 — — 1 7.69
CHEMBL1301481 — — 1 7.68
CHEMBL1340869 — — 1 7.59
CHEMBL1322514 — — 1 7.57
CHEMBL1538061 — — 1 7.54
CHEMBL1577023 — — 2 7.50
CHEMBL1479957 — — 1 7.47
CHEMBL1319376 — — 2 7.45
CHEMBL1439691 — — 1 7.42
CHEMBL1479163 — — 1 7.42
CHEMBL1491674 — — 1 7.41
CHEMBL1598434 — — 1 7.40
CHEMBL1562748 — — 1 7.38
CHEMBL1541608 — — 1 7.36
CHEMBL1506379 — — 1 7.35
CHEMBL1548237 — — 1 7.35
CHEMBL1506229 — — 1 7.34
CHEMBL1462616 — — 1 7.33
CHEMBL1522050 — — 1 7.32
CHEMBL1585368 — — 1 7.31
CHEMBL1327325 — — 1 7.31
CHEMBL1401186 — — 2 7.22
CHEMBL1330871 — — 1 7.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1082607 SALMETEROL XINAFOATE EC50 = 4.49 nM 8.35
CHEMBL1562838 — EC50 = 4.64 nM 8.33
CHEMBL1528906 — EC50 = 7.7 nM 8.11
CHEMBL1444240 — EC50 = 8.16 nM 8.09
CHEMBL1735137 — EC50 = 10.8 nM 7.97
CHEMBL1458579 — EC50 = 11.6 nM 7.94
CHEMBL1339094 — EC50 = 13.3 nM 7.88
CHEMBL1484690 — EC50 = 20.3 nM 7.69
CHEMBL1301481 — EC50 = 20.7 nM 7.68
CHEMBL1340869 — EC50 = 25.5 nM 7.59
CHEMBL1322514 — EC50 = 27.1 nM 7.57
CHEMBL1538061 — EC50 = 29.0 nM 7.54
CHEMBL1577023 — EC50 = 31.6 nM 7.50
CHEMBL1479957 — EC50 = 34.2 nM 7.47
CHEMBL1319376 — EC50 = 35.6 nM 7.45
CHEMBL1439691 — EC50 = 38.0 nM 7.42
CHEMBL1479163 — EC50 = 37.9 nM 7.42
CHEMBL1491674 — EC50 = 39.3 nM 7.41
CHEMBL1598434 — EC50 = 39.6 nM 7.40
CHEMBL1562748 — EC50 = 41.7 nM 7.38
CHEMBL1541608 — EC50 = 43.5 nM 7.36
CHEMBL1548237 — EC50 = 44.4 nM 7.35
CHEMBL1506379 — EC50 = 45.0 nM 7.35
CHEMBL1506229 — EC50 = 45.4 nM 7.34
CHEMBL1462616 — EC50 = 47.2 nM 7.33
CHEMBL1522050 — EC50 = 48.2 nM 7.32
CHEMBL1585368 — EC50 = 49.0 nM 7.31
CHEMBL1327325 — EC50 = 49.2 nM 7.31
CHEMBL1401186 — EC50 = 60.7 nM 7.22
CHEMBL1330871 — EC50 = 60.8 nM 7.22
CHEMBL1577023 — EC50 = 61.1 nM 7.21
CHEMBL1881705 — EC50 = 64.6 nM 7.19
CHEMBL1519042 — EC50 = 67.2 nM 7.17
CHEMBL1452334 — EC50 = 69.3 nM 7.16
CHEMBL1537056 — EC50 = 75.7 nM 7.12
CHEMBL1709014 — EC50 = 77.6 nM 7.11
CHEMBL1319108 — EC50 = 79.8 nM 7.10
CHEMBL1575889 — EC50 = 81.3 nM 7.09
CHEMBL1365203 — EC50 = 80.9 nM 7.09
CHEMBL1570111 — EC50 = 81.0 nM 7.09
CHEMBL1319376 — EC50 = 82.8 nM 7.08
CHEMBL1469574 — EC50 = 91.9 nM 7.04
CHEMBL1456621 — EC50 = 92.7 nM 7.03
CHEMBL1334494 — EC50 = 94.9 nM 7.02
CHEMBL1543973 — EC50 = 107.0 nM 6.97
CHEMBL537445 FENOTEROL HBR EC50 = 110.0 nM 6.96
CHEMBL1379002 — EC50 = 117.0 nM 6.93
CHEMBL1318405 — EC50 = 126.0 nM 6.90
CHEMBL1426242 — EC50 = 133.0 nM 6.88
CHEMBL1577767 — EC50 = 132.0 nM 6.88