Compound Detail
CHEMBL537445
FENOTEROL HBR Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL537445 |
| Name | FENOTEROL HBR |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SGZRQMALQBXAIQ-UHFFFAOYSA-N |
| Parent Compound | CHEMBL32800 |
| Active Moiety | CHEMBL32800 |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
303.4
MW (Da)
2.06
ALogP
5
HBA
5
HBD
93.0
PSA (Ų)
0.56
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.96
IC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-2 adrenergic receptor CHEMBL210 | EC50 | 6.96 | 6.96 | 110.0 | 1 |
| Beta-2 adrenergic receptor CHEMBL5414 | EC50 | 5.09 | 5.09 | 8200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | EC50 | = | 110.0 | nM | 6.96 | PUBCHEM_BIOASSAY: Dose response for HTS for Beta-2AR agonists via FAP method fro... | - |
| Beta-2 adrenergic receptor | EC50 | = | 8200.0 | nM | 5.09 | Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings asse... | 17845020 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 17845020 | 10.1021/jm0704595 | Liver microsomes | 1 |
| 17845020 | 10.1021/jm0704595 | Beta-2 adrenergic receptor | 1 |
| 17417631 | 10.1038/nchembio873 | Unchecked | 1 |
| 20553011 | 10.1021/tx1000865 | Hepatotoxicity | 1 |
| 20843939 | 10.1124/dmd.110.035113 | Hepatotoxicity | 1 |
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine