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Assay Detail

CHEMBL1798372

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of c-MET assessed as incorporation of p33 using [gammaP33]-ATP by microplate scintillation counting
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Hepatocyte growth factor receptor (CHEMBL3717)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure.
Schmidt S, Preu L, Lemcke T, Totzke F, Schächtele C, Kubbutat MH, Kunick C.
Eur J Med Chem (2011) 46 : 2759 -2769
PubMed 21524503 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 4.62 5.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1796191 1 5.39
CHEMBL1796189 1 5.28
CHEMBL1796190 1 5.12
CHEMBL1796192 1 5.06
CHEMBL1796188 1 4.89
CHEMBL1796183 1 4.85
CHEMBL1796185 1 4.80
CHEMBL1796193 1 4.57
CHEMBL1796180 1 4.44
CHEMBL1796182 1 4.32
CHEMBL1796181 1 4.31
CHEMBL1796172 1 4.16
CHEMBL1796179 1 4.02
CHEMBL1796186 1 4.02
CHEMBL1796178 1 4.02
CHEMBL72505 1 -
CHEMBL124871 1 -
CHEMBL1796173 1 -
CHEMBL1796174 1 -
CHEMBL75289 1 -
CHEMBL220737 1 -
CHEMBL1796187 1 -
CHEMBL73288 1 -
CHEMBL358147 1 -
CHEMBL1796184 1 -
CHEMBL1796175 1 -
CHEMBL71999 1 -
CHEMBL71184 1 -
CHEMBL1796176 1 -
CHEMBL1796177 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1796191 IC50 = 4100.0 nM 5.39
CHEMBL1796189 IC50 = 5200.0 nM 5.28
CHEMBL1796190 IC50 = 7600.0 nM 5.12
CHEMBL1796192 IC50 = 8800.0 nM 5.06
CHEMBL1796188 IC50 = 13000.0 nM 4.89
CHEMBL1796183 IC50 = 14000.0 nM 4.85
CHEMBL1796185 IC50 = 16000.0 nM 4.80
CHEMBL1796193 IC50 = 27000.0 nM 4.57
CHEMBL1796180 IC50 = 36000.0 nM 4.44
CHEMBL1796182 IC50 = 48000.0 nM 4.32
CHEMBL1796181 IC50 = 49000.0 nM 4.31
CHEMBL1796172 IC50 = 69000.0 nM 4.16
CHEMBL1796179 IC50 = 96000.0 nM 4.02
CHEMBL1796186 IC50 = 95000.0 nM 4.02
CHEMBL1796178 IC50 = 95000.0 nM 4.02
CHEMBL72505 IC50 > 100000.0 nM -
CHEMBL124871 IC50 > 100000.0 nM -
CHEMBL1796173 IC50 > 100000.0 nM -
CHEMBL1796174 IC50 > 100000.0 nM -
CHEMBL75289 IC50 > 100000.0 nM -
CHEMBL220737 IC50 > 100000.0 nM -
CHEMBL1796187 IC50 > 100000.0 nM -
CHEMBL73288 IC50 > 100000.0 nM -
CHEMBL358147 IC50 > 100000.0 nM -
CHEMBL1796184 IC50 > 100000.0 nM -
CHEMBL1796175 IC50 > 100000.0 nM -
CHEMBL71999 IC50 > 100000.0 nM -
CHEMBL71184 IC50 > 100000.0 nM -
CHEMBL1796176 IC50 > 100000.0 nM -
CHEMBL1796177 IC50 > 100000.0 nM -