Compound Detail
CHEMBL72505
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Basic Information
| ChEMBL ID | CHEMBL72505 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MEGFWOULWCPKJU-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
279.3
MW (Da)
2.49
ALogP
3
HBA
3
HBD
74.0
PSA (Ų)
0.39
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL2094107 | Ki | 6.69 | 6.69 | 203.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 203.0 | nM | 6.69 | Inhibition of [3H]-Ro- 15-1788 binding to GABA-A benzodiazepine receptor of bovi... | 9748357 |
| GABA-A receptor; anion channel | Ki | = | 203.0 | nM | 6.69 | Inhibition of [3H]- flumazenil binding to benzodiazepine receptor in bovine brai... | 11428922 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9748357 | 10.1021/jm9800301 | GABA-A receptor; anion channel | 3 |
| 11428922 | 10.1021/jm010827j | GABA-A receptor; anion channel | 2 |
| 21524503 | 10.1016/j.ejmech.2011.03.065 | Hepatocyte growth factor receptor | 1 |
| 21524503 | 10.1016/j.ejmech.2011.03.065 | Insulin-like growth factor 1 receptor | 1 |
| 21524503 | 10.1016/j.ejmech.2011.03.065 | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine