Assay Detail
Binding
CHEMBL650823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-Ro- 15-1788 binding to GABA-A benzodiazepine receptor of bovine brain membranes
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Subcellular | Brain membranes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2094107) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
Publication
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.81 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308760 | — | — | 1 | 7.96 |
| CHEMBL74448 | — | — | 1 | 7.96 |
| CHEMBL75212 | — | — | 1 | 7.52 |
| CHEMBL75306 | — | — | 1 | 7.28 |
| CHEMBL127135 | — | — | 1 | 7.28 |
| CHEMBL124323 | — | — | 1 | 7.24 |
| CHEMBL124871 | — | — | 1 | 7.21 |
| CHEMBL73288 | — | — | 1 | 7.17 |
| CHEMBL306370 | — | — | 1 | 7.03 |
| CHEMBL74280 | — | — | 1 | 6.97 |
| CHEMBL75307 | — | — | 1 | 6.93 |
| CHEMBL75289 | — | — | 1 | 6.92 |
| CHEMBL306310 | — | — | 1 | 6.79 |
| CHEMBL72505 | — | — | 1 | 6.69 |
| CHEMBL332059 | — | — | 1 | 6.54 |
| CHEMBL74013 | — | — | 1 | 6.37 |
| CHEMBL127519 | — | — | 1 | 6.34 |
| CHEMBL74589 | — | — | 1 | 6.31 |
| CHEMBL127359 | — | — | 1 | 6.29 |
| CHEMBL124212 | — | — | 1 | 5.92 |
| CHEMBL123802 | — | — | 1 | 5.62 |
| CHEMBL337913 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308760 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL74448 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL75212 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL75306 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL127135 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL124323 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL124871 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL73288 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL306370 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL74280 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL75307 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL75289 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL306310 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL72505 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL332059 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL74013 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL127519 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL74589 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL127359 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL124212 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL123802 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL337913 | — | Ki | = | 3400.0 | nM | 5.47 |