Assay Detail
Binding
CHEMBL1798511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of histone acetylase activity of human recombinant PCAF expressed in Escherichia coli using biotinylated oligopeptide sequences from histone H4 (2-24) substrate by In-vitro time-resolved fluorescence immunosorbent acetyltransferase assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.34 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106011 | — | — | 1 | 6.14 |
| CHEMBL1795605 | — | — | 1 | 6.07 |
| CHEMBL1795609 | — | — | 1 | 5.74 |
| CHEMBL1795611 | — | — | 1 | 5.57 |
| CHEMBL99137 | — | — | 1 | 5.52 |
| CHEMBL1795606 | — | — | 1 | 4.80 |
| CHEMBL1795624 | — | — | 1 | 4.59 |
| CHEMBL1795799 | — | — | 1 | 4.29 |
| CHEMBL1732009 | — | — | 1 | - |
| CHEMBL1795610 | — | — | 1 | - |
| CHEMBL1795802 | — | — | 1 | - |
| CHEMBL1795619 | — | — | 1 | - |
| CHEMBL1795618 | — | — | 1 | - |
| CHEMBL98663 | — | — | 1 | - |
| CHEMBL1795617 | — | — | 1 | - |
| CHEMBL102387 | — | — | 1 | - |
| CHEMBL1795615 | — | — | 1 | - |
| CHEMBL1795613 | — | — | 1 | - |
| CHEMBL1795612 | — | — | 1 | - |
| CHEMBL1795801 | — | — | 1 | - |
| CHEMBL1795800 | — | — | 1 | - |
| CHEMBL1795798 | — | — | 1 | - |
| CHEMBL1795796 | — | — | 1 | - |
| CHEMBL1795795 | — | — | 1 | - |
| CHEMBL1795625 | — | — | 1 | - |
| CHEMBL1795623 | — | — | 1 | - |
| CHEMBL1795622 | — | — | 1 | - |
| CHEMBL1795621 | — | — | 1 | - |
| CHEMBL1370704 | — | — | 1 | - |
| CHEMBL1795620 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106011 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1795605 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1795609 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL1795611 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL99137 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL1795606 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1795624 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL1795799 | — | IC50 | = | 51300.0 | nM | 4.29 |
| CHEMBL1795618 | — | IC50 | - | — | - | |
| CHEMBL1795604 | — | IC50 | - | — | - | |
| CHEMBL98663 | — | IC50 | - | — | - | |
| CHEMBL1795617 | — | IC50 | - | — | - | |
| CHEMBL102387 | — | IC50 | - | — | - | |
| CHEMBL1795615 | — | IC50 | - | — | - | |
| CHEMBL1795613 | — | IC50 | - | — | - | |
| CHEMBL1795612 | — | IC50 | - | — | - | |
| CHEMBL1795610 | — | IC50 | - | — | - | |
| CHEMBL95284 | — | IC50 | - | — | - | |
| CHEMBL1795608 | — | IC50 | - | — | - | |
| CHEMBL1795607 | — | IC50 | - | — | - | |
| CHEMBL101422 | — | IC50 | - | — | - | |
| CHEMBL1795619 | — | IC50 | - | — | - | |
| CHEMBL1795802 | — | IC50 | - | — | - | |
| CHEMBL1732009 | — | IC50 | - | — | - | |
| CHEMBL1795801 | — | IC50 | - | — | - | |
| CHEMBL1795800 | — | IC50 | - | — | - | |
| CHEMBL1795798 | — | IC50 | - | — | - | |
| CHEMBL1795796 | — | IC50 | - | — | - | |
| CHEMBL1795795 | — | IC50 | - | — | - | |
| CHEMBL1795625 | — | IC50 | - | — | - | |
| CHEMBL1795623 | — | IC50 | - | — | - | |
| CHEMBL1795622 | — | IC50 | - | — | - | |
| CHEMBL1795621 | — | IC50 | - | — | - | |
| CHEMBL1370704 | — | IC50 | - | — | - | |
| CHEMBL1795620 | — | IC50 | - | — | - |