Compound Detail
CHEMBL1370704
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Basic Information
| ChEMBL ID | CHEMBL1370704 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IKEJORUOOGOBMU-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
347.8
MW (Da)
3.37
ALogP
5
HBA
1
HBD
64.0
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.36
EC50 1 meas. best 5.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CREB-binding protein CHEMBL5747 | IC50 | 6.36 | 6.36 | 440.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.86 | 5.86 | 1390.0 | 1 |
| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase CHEMBL1741212 | IC50 | 5.6 | 5.6 | 2510.0 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G CHEMBL1741217 | IC50 | 5.47 | 5.47 | 3350.0 | 1 |
| Glucose-6-phosphate 1-dehydrogenase CHEMBL5347 | IC50 | 4.68 | 4.68 | 20700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CREB-binding protein | IC50 | = | 440.0 | nM | 6.36 | Inhibition of recombinant human CBP using biotinylated histone H3 (1 to 21 amino... | - |
| Unchecked | EC50 | = | 1390.0 | nM | 5.86 | PUBCHEM_BIOASSAY: Luminescence Cell-Based/Microorganism Dose Confirmation HTS to... | - |
| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | IC50 | = | 2510.0 | nM | 5.6 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
| DNA dC->dU-editing enzyme APOBEC-3G | IC50 | = | 3350.0 | nM | 5.47 | PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3G DNA Deam... | - |
| Glucose-6-phosphate 1-dehydrogenase | IC50 | = | 20700.0 | nM | 4.68 | PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectiv... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21353783 | 10.1016/j.bmc.2011.01.063 | Histone acetyltransferase KAT2B | 2 |
| - | 10.1039/C4MD00245H | CREB-binding protein | 2 |
| 21353783 | 10.1016/j.bmc.2011.01.063 | SK-N-SH | 1 |
| 21353783 | 10.1016/j.bmc.2011.01.063 | HCT-116 | 1 |
| 21353783 | 10.1016/j.bmc.2011.01.063 | MCF7 | 1 |
| - | 10.1039/C4MD00245H | Histone acetyltransferase KAT2B | 1 |
| - | 10.1039/C4MD00245H | Histone acetyltransferase KAT2A | 1 |
| - | 10.1039/C4MD00245H | Histone acetyltransferase p300 | 1 |
| - | 10.1039/C4MD00245H | HL-60 | 1 |
| - | 10.1039/C4MD00245H | LNCaP | 1 |
Data from ChEMBL 36 via Core Engine