Assay Detail
Binding
CHEMBL1799575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum homogenate by scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.51 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1797687 | — | — | 1 | 10.52 |
| CHEMBL1797689 | — | — | 1 | 10.42 |
| CHEMBL490665 | NALFURAFINE HYDROCHLORIDE | 4.0 | 1 | 9.64 |
| CHEMBL1797688 | — | — | 1 | 9.47 |
| CHEMBL560 | — | — | 1 | 8.44 |
| CHEMBL1797684 | — | — | 1 | 7.76 |
| CHEMBL1797686 | — | — | 1 | 7.66 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.33 |
| CHEMBL963 | OXYMORPHONE | 4.0 | 1 | 7.24 |
| CHEMBL1797685 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1797687 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL1797689 | — | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL490665 | NALFURAFINE HYDROCHLORIDE | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL1797688 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL560 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1797684 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL1797686 | — | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL70 | MORPHINE | Ki | = | 46.9 | nM | 7.33 |
| CHEMBL963 | OXYMORPHONE | Ki | = | 57.6 | nM | 7.24 |
| CHEMBL1797685 | — | Ki | = | 255.0 | nM | 6.59 |