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Compound Detail

CHEMBL1797689

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O=C1CC[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)C1

Basic Information

ChEMBL ID CHEMBL1797689
Phase Preclinical
Structure Type MOL
InChI Key JKSUUZMNWGEVRC-VAMGGRTRSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

327.4
MW (Da)
2.15
ALogP
4
HBA
2
HBD
60.8
PSA (Ų)
0.87
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H25NO3
MW 327.42
Aromatic Rings 1
Heavy Atoms 24
NP-Likeness 1.48

Activity Summary

Ki 6 meas. best 10.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Kappa-type opioid receptor
CHEMBL3952
Ki 10.42 10.42 0.0 1
Mu-type opioid receptor
CHEMBL4354
Ki 9.85 9.85 0.1 1
Kappa-type opioid receptor
CHEMBL237
Ki 9.19 9.19 0.6 1
Mu-type opioid receptor
CHEMBL233
Ki 9.11 9.11 0.8 1
Unchecked
CHEMBL612545
Ki 8.74 8.74 1.8 1
Delta-type opioid receptor
CHEMBL236
Ki 8.58 8.58 2.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21641798 10.1016/j.bmcl.2011.04.147 Unchecked 2
27079125 10.1016/j.bmc.2016.03.040 Unchecked 2
21641798 10.1016/j.bmcl.2011.04.147 Mu-type opioid receptor 1
21641798 10.1016/j.bmcl.2011.04.147 Kappa-type opioid receptor 1
21641798 10.1016/j.bmcl.2011.04.147 Opioid receptor (mu and kappa) 1
27079125 10.1016/j.bmc.2016.03.040 Mu-type opioid receptor 1
27079125 10.1016/j.bmc.2016.03.040 Delta-type opioid receptor 1
27079125 10.1016/j.bmc.2016.03.040 Kappa-type opioid receptor 1

Data from ChEMBL 36 via Core Engine