Assay Detail
Functional
CHEMBL1803443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.54 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 10.20 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.89 |
| CHEMBL1802510 | — | — | 1 | 8.07 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.00 |
| CHEMBL1802509 | — | — | 1 | 7.60 |
| CHEMBL1802998 | — | — | 1 | 7.24 |
| CHEMBL1802501 | — | — | 1 | 7.24 |
| CHEMBL1802503 | — | — | 1 | 7.24 |
| CHEMBL1802511 | — | — | 1 | 7.18 |
| CHEMBL1802500 | — | — | 1 | 7.14 |
| CHEMBL1803003 | — | — | 1 | 6.77 |
| CHEMBL1802565 | — | — | 1 | 6.26 |
| CHEMBL1802577 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.063 | nM | 10.20 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1802510 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL107 | COLCHICINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1802509 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1802998 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1802501 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1802503 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1802511 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1802500 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1803003 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1802565 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1802577 | — | IC50 | = | 650.0 | nM | 6.19 |