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Assay Detail

CHEMBL1803671

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Functional
Antiproliferative activity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Autocuration

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.
Romagnoli R, Baraldi PG, Brancale A, Ricci A, Hamel E, Bortolozzi R, Basso G, Viola G.
J Med Chem (2011) 54 : 5144 -5153
PubMed 21663319 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 8.03 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1800843 1 10.22
CHEMBL1800842 1 9.85
CHEMBL1800719 1 9.22
CHEMBL1800723 1 8.68
CHEMBL1800726 1 8.54
CHEMBL1800718 1 8.48
CHEMBL1800720 1 8.41
CHEMBL1800721 1 8.39
CHEMBL67 COMBRETASTATIN A4 -1.0 1 8.30
CHEMBL1800725 1 8.14
CHEMBL1800722 1 8.07
CHEMBL1800840 1 7.67
CHEMBL1800724 1 7.32
CHEMBL1800841 1 6.50
CHEMBL1800716 1 5.42
CHEMBL1800717 1 5.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1800843 IC50 = 0.06 nM 10.22
CHEMBL1800842 IC50 = 0.14 nM 9.85
CHEMBL1800719 IC50 = 0.6 nM 9.22
CHEMBL1800723 IC50 = 2.1 nM 8.68
CHEMBL1800726 IC50 = 2.9 nM 8.54
CHEMBL1800718 IC50 = 3.3 nM 8.48
CHEMBL1800720 IC50 = 3.9 nM 8.41
CHEMBL1800721 IC50 = 4.1 nM 8.39
CHEMBL67 COMBRETASTATIN A4 IC50 = 5.0 nM 8.30
CHEMBL1800725 IC50 = 7.3 nM 8.14
CHEMBL1800722 IC50 = 8.5 nM 8.07
CHEMBL1800840 IC50 = 21.5 nM 7.67
CHEMBL1800724 IC50 = 48.4 nM 7.32
CHEMBL1800841 IC50 = 319.0 nM 6.50
CHEMBL1800716 IC50 = 3834.0 nM 5.42
CHEMBL1800717 IC50 = 4691.0 nM 5.33