Assay Detail
Functional
CHEMBL1804513
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Agonist activity beta2-adrenergic receptor in rat ventricular myocytes assessed as cell contraction following electrical stimulation by optical edge tracking method using photodiode array
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.71 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800963 | — | — | 1 | 7.80 |
| CHEMBL229401 | — | — | 1 | 7.23 |
| CHEMBL388570 | — | — | 1 | 7.14 |
| CHEMBL229614 | — | — | 1 | 6.99 |
| CHEMBL1800961 | — | — | 1 | 6.88 |
| CHEMBL228992 | — | — | 1 | 6.73 |
| CHEMBL228996 | — | — | 1 | 6.30 |
| CHEMBL229476 | — | — | 1 | 6.24 |
| CHEMBL1800936 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800963 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL229401 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL388570 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL229614 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL1800961 | — | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL228992 | — | EC50 | = | 186.0 | nM | 6.73 |
| CHEMBL228996 | — | EC50 | = | 506.0 | nM | 6.30 |
| CHEMBL229476 | — | EC50 | = | 575.0 | nM | 6.24 |
| CHEMBL1800936 | — | EC50 | = | 8551.0 | nM | 5.07 |