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Compound Detail

CHEMBL1800936

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CC[C@H](Cc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc(O)c1

Basic Information

ChEMBL ID CHEMBL1800936
Phase Preclinical
Structure Type MOL
InChI Key KFRXJKMLZFERKO-KDOFPFPSSA-N
2
Targets
7
Activities
3
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

317.4
MW (Da)
2.45
ALogP
5
HBA
5
HBD
93.0
PSA (Ų)
0.54
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H23NO4
MW 317.39
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness 0.54

Activity Summary

Ki 4 meas. best 7.41
EC50 2 meas. best 8.55
IC50 1 meas. best 8.84

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
IC50 8.84 8.84 1.4 1
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.55 8.55 2.8 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 7.41 6.9067 39.1 3
Beta-2 adrenergic receptor
CHEMBL3754
EC50 5.07 5.07 8551.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20036561 10.1016/j.bmc.2009.11.062 Beta-2 adrenergic receptor 6
24326276 10.1016/j.bmc.2013.11.030 Beta-2 adrenergic receptor 3
20036561 10.1016/j.bmc.2009.11.062 Beta-1 adrenergic receptor 1
20036561 10.1016/j.bmc.2009.11.062 Unchecked 1

Data from ChEMBL 36 via Core Engine