Assay Detail
Functional
CHEMBL1804511
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Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 8.53 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388570 | — | — | 1 | 9.52 |
| CHEMBL228992 | — | — | 1 | 9.52 |
| CHEMBL1800961 | — | — | 1 | 9.40 |
| CHEMBL228996 | — | — | 1 | 8.70 |
| CHEMBL229614 | — | — | 1 | 8.57 |
| CHEMBL1800936 | — | — | 1 | 8.55 |
| CHEMBL1800963 | — | — | 1 | 8.41 |
| CHEMBL1800934 | — | — | 1 | 8.40 |
| CHEMBL229476 | — | — | 1 | 8.33 |
| CHEMBL228998 | — | — | 1 | 8.14 |
| CHEMBL1800962 | — | — | 1 | 8.12 |
| CHEMBL229477 | — | — | 1 | 8.07 |
| CHEMBL229401 | — | — | 1 | 7.90 |
| CHEMBL1800960 | — | — | 1 | 7.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388570 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL228992 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1800961 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL228996 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL229614 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1800936 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1800963 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1800934 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL229476 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL228998 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1800962 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL229477 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL229401 | — | EC50 | = | 12.5 | nM | 7.90 |
| CHEMBL1800960 | — | EC50 | = | 16.6 | nM | 7.78 |