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Compound Detail

CHEMBL1800934

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COc1ccc(C[C@H](C)NC[C@H](O)c2cc(O)cc(O)c2)c2ccccc12

Basic Information

ChEMBL ID CHEMBL1800934
Phase Preclinical
Structure Type MOL
InChI Key MLQLUFQBFMFXJO-QKKBWIMNSA-N
2
Targets
6
Activities
3
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

367.4
MW (Da)
3.51
ALogP
5
HBA
4
HBD
82.0
PSA (Ų)
0.51
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25NO4
MW 367.45
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness 0.21

Activity Summary

Ki 4 meas. best 7.9
EC50 1 meas. best 8.4
IC50 1 meas. best 8.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.4 8.4 4.0 1
Beta-2 adrenergic receptor
CHEMBL210
IC50 8.36 8.36 4.4 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 7.9 7.4333 12.7 3
Beta-1 adrenergic receptor
CHEMBL3252
Ki 4.83 4.83 14800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20036561 10.1016/j.bmc.2009.11.062 Beta-2 adrenergic receptor 3
24326276 10.1016/j.bmc.2013.11.030 Beta-2 adrenergic receptor 3
20036561 10.1016/j.bmc.2009.11.062 Beta-1 adrenergic receptor 1
20036561 10.1016/j.bmc.2009.11.062 Unchecked 1

Data from ChEMBL 36 via Core Engine