Assay Detail
Binding
CHEMBL1805307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802632 | — | — | 1 | 8.70 |
| CHEMBL1088751 | PH-797804 | 2.0 | 3 | 8.64 |
| CHEMBL1802637 | — | — | 1 | 8.52 |
| CHEMBL1802641 | — | — | 1 | 8.40 |
| CHEMBL1802636 | — | — | 1 | 8.07 |
| CHEMBL1802633 | — | — | 1 | 8.02 |
| CHEMBL1797224 | — | — | 1 | 7.92 |
| CHEMBL1802638 | — | — | 1 | 7.68 |
| CHEMBL1802634 | — | — | 1 | 7.47 |
| CHEMBL1802635 | — | — | 1 | 7.31 |
| CHEMBL1802640 | — | — | 1 | 6.49 |
| CHEMBL1802639 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802632 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1088751 | PH-797804 | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1088751 | PH-797804 | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1802637 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1802641 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1802636 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1802633 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL1797224 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1802638 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1802634 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1802635 | — | IC50 | = | 48.5 | nM | 7.31 |
| CHEMBL1088751 | PH-797804 | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL1802640 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL1802639 | — | IC50 | > | 10000.0 | nM | - |