Compound Detail
CHEMBL1802633
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1802633 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KOCGXDXBMZBMRZ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
491.3
MW (Da)
4.78
ALogP
4
HBA
0
HBD
51.5
PSA (Ų)
0.52
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.02 | 8.02 | 9.5 | 1 |
| PBMC CHEMBL613107 | IC50 | 7.54 | 7.54 | 28.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 9.5 | nM | 8.02 | Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 m... | 21641211 |
| PBMC | IC50 | = | 28.5 | nM | 7.54 | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TN... | 21641211 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21641211 | 10.1016/j.bmcl.2011.04.121 | Liver microsomes | 2 |
| 21641211 | 10.1016/j.bmcl.2011.04.121 | Rattus norvegicus | 2 |
| 21641211 | 10.1016/j.bmcl.2011.04.121 | Mitogen-activated protein kinase 14 | 1 |
| 21641211 | 10.1016/j.bmcl.2011.04.121 | PBMC | 1 |
Data from ChEMBL 36 via Core Engine