Assay Detail
ADMET
CHEMBL1805702
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Competitive inhibition of CYP2C9
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.22 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253083 | — | — | 2 | 5.77 |
| CHEMBL485629 | MK-0873 | 2.0 | 1 | 4.40 |
| CHEMBL372575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253083 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL253083 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL485629 | MK-0873 | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL372575 | — | IC50 | < | 1000.0 | nM | - |