Assay Detail
Functional
CHEMBL1809335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against acyclovir-resistant TK-deficient Herpes simplex virus-1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 4.82 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.10 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.70 |
| CHEMBL1807156 | — | — | 1 | 4.70 |
| CHEMBL1807153 | — | — | 1 | 4.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.30 |
| CHEMBL1807154 | — | — | 1 | 4.14 |
| CHEMBL1807155 | — | — | 1 | 4.11 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL1807162 | — | — | 1 | - |
| CHEMBL1807160 | — | — | 1 | - |
| CHEMBL1807161 | — | — | 1 | - |
| CHEMBL1807159 | — | — | 1 | - |
| CHEMBL1807158 | — | — | 1 | - |
| CHEMBL1807157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1807156 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1807153 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1807154 | — | EC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL1807155 | — | EC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 250000.0 | nM | - |
| CHEMBL1807162 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1807160 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1807161 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1807159 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL1807158 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1807157 | — | EC50 | >= | 100000.0 | nM | - |