Assay Detail
Functional
CHEMBL1809336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Feline herpesvirus infected in cat CRFK cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Felid alphaherpesvirus 1 |
| Cell Type | CRFK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.30 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.00 |
| CHEMBL1807153 | — | — | 1 | 5.92 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.89 |
| CHEMBL1807154 | — | — | 1 | 5.62 |
| CHEMBL1807157 | — | — | 1 | 5.36 |
| CHEMBL1807161 | — | — | 1 | 4.94 |
| CHEMBL1807155 | — | — | 1 | 4.89 |
| CHEMBL1807158 | — | — | 1 | 4.55 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 4.52 |
| CHEMBL1807162 | — | — | 1 | - |
| CHEMBL1807160 | — | — | 1 | - |
| CHEMBL1807159 | — | — | 1 | - |
| CHEMBL1807156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1807153 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1807154 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1807157 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1807161 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL1807155 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1807158 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1807162 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1807160 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL1807159 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL1807156 | — | EC50 | > | 100000.0 | nM | - |