Assay Detail
Binding
CHEMBL1811510
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Inhibition of TPA-induced AP-1 activity expressed in human HEK293T cells treated 1 hr before TPA challenge measured after 18 hrs by FRET based beta-lactamase reporter assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK-293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.36 | 6.89 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458347 | GLAUCARUBINONE | — | 2 | 6.89 |
| CHEMBL1807644 | NOTHOSPONDIN | — | 2 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458347 | GLAUCARUBINONE | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1807644 | NOTHOSPONDIN | EC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL1807644 | NOTHOSPONDIN | Inhibition | - | % | - | |
| CHEMBL458347 | GLAUCARUBINONE | Inhibition | - | % | - |