Compound Detail
CHEMBL1807644
NOTHOSPONDIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1807644 |
| Name | NOTHOSPONDIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CWVPFDLFQUVWQC-ZUEPXWORSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
392.4
MW (Da)
1.01
ALogP
7
HBA
2
HBD
110.1
PSA (Ų)
0.64
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.89
IC50 1 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transcription factor Jun CHEMBL4977 | EC50 | 6.89 | 6.36 | 130.0 | 2 |
| HEK-293T CHEMBL3706568 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transcription factor Jun | EC50 | = | 130.0 | nM | 6.89 | Inhibition of AP-1 (unknown origin) by FRET assay | 24831826 |
| Transcription factor Jun | EC50 | = | 1490.0 | nM | 5.83 | Inhibition of TPA-induced AP-1 activity expressed in human HEK293T cells treated... | 21733691 |
| HEK-293T | IC50 | = | 10000.0 | nM | 5.0 | Cytotoxicity against human HEK293T cells expressing AP-1 after 18 hrs by XTT ass... | 21733691 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21733691 | 10.1016/j.bmcl.2011.06.044 | Transcription factor Jun | 2 |
| 21733691 | 10.1016/j.bmcl.2011.06.044 | HEK-293T | 1 |
| 24831826 | 10.1021/jm5004733 | Transcription factor Jun | 1 |
Data from ChEMBL 36 via Core Engine