Assay Detail
ADMET
CHEMBL1815844
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Inhibition of CYP2D6
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.73 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090526 | — | — | 1 | 5.19 |
| CHEMBL1090176 | — | — | 1 | 4.96 |
| CHEMBL1092662 | — | — | 1 | 4.66 |
| CHEMBL564144 | — | — | 1 | 4.55 |
| CHEMBL556506 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090526 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1090176 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1092662 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL564144 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL556506 | — | IC50 | = | 50000.0 | nM | 4.30 |