Assay Detail
Functional
CHEMBL1815950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 4.40 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813447 | — | — | 1 | 4.70 |
| CHEMBL1813443 | — | — | 1 | 4.64 |
| CHEMBL1813446 | — | — | 1 | 4.64 |
| CHEMBL1813438 | — | — | 1 | 4.60 |
| CHEMBL1813435 | — | — | 1 | 4.58 |
| CHEMBL1813449 | — | — | 1 | 4.55 |
| CHEMBL1813448 | — | — | 1 | 4.52 |
| CHEMBL1813440 | — | — | 1 | 4.50 |
| CHEMBL1813439 | — | — | 1 | 4.48 |
| CHEMBL1813454 | — | — | 1 | 4.48 |
| CHEMBL1813434 | — | — | 1 | 4.47 |
| CHEMBL1668019 | APLAVIROC HYDROCHLORIDE | 3.0 | 1 | 4.47 |
| CHEMBL1813432 | — | — | 1 | 4.42 |
| CHEMBL1813271 | — | — | 1 | 4.41 |
| CHEMBL1668020 | — | — | 1 | 4.36 |
| CHEMBL1813457 | — | — | 1 | 4.34 |
| CHEMBL1813433 | — | — | 1 | 4.32 |
| CHEMBL1813436 | — | — | 1 | 4.32 |
| CHEMBL1813444 | — | — | 1 | 4.30 |
| CHEMBL1668022 | — | — | 1 | 4.29 |
| CHEMBL1813445 | — | — | 1 | 4.23 |
| CHEMBL1813450 | — | — | 1 | 4.17 |
| CHEMBL1813270 | — | — | 1 | 4.17 |
| CHEMBL1813437 | — | — | 1 | 4.09 |
| CHEMBL1813269 | — | — | 1 | 4.04 |
| CHEMBL536754 | — | — | 1 | - |
| CHEMBL1813441 | — | — | 1 | - |
| CHEMBL1813442 | — | — | 1 | - |
| CHEMBL1813451 | — | — | 1 | - |
| CHEMBL1813452 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813447 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1813443 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1813446 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1813438 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1813435 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1813449 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1813448 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1813440 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1813439 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1813454 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1813434 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1668019 | APLAVIROC HYDROCHLORIDE | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1813432 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1813271 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1668020 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1813457 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1813436 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1813433 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1813444 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1668022 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL1813445 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL1813450 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL1813270 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL1813437 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL1813269 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL1668021 | — | IC50 | = | 470000.0 | nM | - |
| CHEMBL1813458 | — | IC50 | = | 270000.0 | nM | - |
| CHEMBL3215636 | — | IC50 | = | 640000.0 | nM | - |
| CHEMBL3216516 | — | IC50 | = | 750000.0 | nM | - |
| CHEMBL1813453 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL1813452 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL1813451 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL1813442 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL1813441 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL536754 | — | IC50 | = | 53000.0 | nM | - |