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Assay Detail

CHEMBL1816534

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against VZV 07/1 infected in HEL cells assessed as protection against virus-induced cytopathicity
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Cell Type HEL
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 3 (CHEMBL613132)
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

New prodrugs of Adefovir and Cidofovir.
Tichý T, Andrei G, Dračínský M, Holý A, Balzarini J, Snoeck R, Krečmerová M.
Bioorg Med Chem (2011) 19 : 3527 -3539
PubMed 21565516 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 5.06 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5314375 CIDOFOVIR 4.0 1 7.00
CHEMBL1814569 1 6.22
CHEMBL1814570 1 6.19
CHEMBL484 ADEFOVIR 3.0 1 5.30
CHEMBL1814568 1 5.12
CHEMBL1814560 1 4.74
CHEMBL1814564 1 4.39
CHEMBL1814559 1 4.22
CHEMBL1814556 1 4.19
CHEMBL1814565 1 4.16
CHEMBL184 ACYCLOVIR 4.0 1 4.16
CHEMBL1814566 1 -
CHEMBL182 GANCICLOVIR 4.0 1 -
CHEMBL31634 BRIVUDINE 2.0 1 -
CHEMBL1814567 1 -
CHEMBL1814563 1 -
CHEMBL1814562 1 -
CHEMBL1814561 1 -
CHEMBL1814558 1 -
CHEMBL1814557 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5314375 CIDOFOVIR EC50 = 100.0 nM 7.00
CHEMBL1814569 EC50 = 600.0 nM 6.22
CHEMBL1814570 EC50 = 640.0 nM 6.19
CHEMBL484 ADEFOVIR EC50 = 5000.0 nM 5.30
CHEMBL1814568 EC50 = 7600.0 nM 5.12
CHEMBL1814560 EC50 = 18400.0 nM 4.74
CHEMBL1814564 EC50 = 40900.0 nM 4.39
CHEMBL1814559 EC50 = 60700.0 nM 4.22
CHEMBL1814556 EC50 = 64300.0 nM 4.19
CHEMBL1814565 EC50 = 69000.0 nM 4.16
CHEMBL184 ACYCLOVIR EC50 = 69300.0 nM 4.16
CHEMBL1814566 EC50 > 125000.0 nM -
CHEMBL182 GANCICLOVIR EC50 - -
CHEMBL31634 BRIVUDINE EC50 >= 105400.0 nM -
CHEMBL1814567 EC50 > 117000.0 nM -
CHEMBL1814563 EC50 > 142000.0 nM -
CHEMBL1814562 EC50 > 29700.0 nM -
CHEMBL1814561 EC50 >= 72700.0 nM -
CHEMBL1814558 EC50 > 34000.0 nM -
CHEMBL1814557 EC50 > 224000.0 nM -