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Assay Detail

CHEMBL1817182

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CCRF-CEM cells after 3 days by XTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Bourderioux A, Naus P, Perlíková P, Pohl R, Pichová I, Votruba I, Dzubák P, Konecný P, Hajdúch M, Stray KM, Wang T, Ray AS, Feng JY, Birkus G, Cihlar T, Hocek M.
J Med Chem (2011) 54 : 5498 -5507
PubMed 21711054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.00 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1814776 1 8.00
CHEMBL1814778 1 7.70
CHEMBL1814768 1 7.30
CHEMBL1814777 1 7.22
CHEMBL1814780 1 7.16
CHEMBL1814779 1 7.16
CHEMBL1814769 1 7.16
CHEMBL1814767 1 7.00
CHEMBL1814773 1 6.96
CHEMBL1814770 1 6.96
CHEMBL1814775 1 6.89
CHEMBL1814772 1 6.80
CHEMBL1814774 1 6.25
CHEMBL1814771 1 5.40
CHEMBL1814762 1 -
CHEMBL1814766 1 -
CHEMBL1814765 1 -
CHEMBL1814764 1 -
CHEMBL1814763 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1814776 IC50 = 10.0 nM 8.00
CHEMBL1814778 IC50 = 20.0 nM 7.70
CHEMBL1814768 IC50 = 50.0 nM 7.30
CHEMBL1814777 IC50 = 60.0 nM 7.22
CHEMBL1814780 IC50 = 70.0 nM 7.16
CHEMBL1814779 IC50 = 70.0 nM 7.16
CHEMBL1814769 IC50 = 70.0 nM 7.16
CHEMBL1814767 IC50 = 100.0 nM 7.00
CHEMBL1814773 IC50 = 110.0 nM 6.96
CHEMBL1814770 IC50 = 110.0 nM 6.96
CHEMBL1814775 IC50 = 130.0 nM 6.89
CHEMBL1814772 IC50 = 160.0 nM 6.80
CHEMBL1814774 IC50 = 560.0 nM 6.25
CHEMBL1814771 IC50 = 3950.0 nM 5.40
CHEMBL1814762 IC50 > 10000.0 nM -
CHEMBL1814766 IC50 > 10000.0 nM -
CHEMBL1814765 IC50 > 10000.0 nM -
CHEMBL1814764 IC50 > 10000.0 nM -
CHEMBL1814763 IC50 > 10000.0 nM -