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Assay Detail

CHEMBL1817183

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human ADK using [3H]-adenosine by scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine kinase (CHEMBL3589)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Bourderioux A, Naus P, Perlíková P, Pohl R, Pichová I, Votruba I, Dzubák P, Konecný P, Hajdúch M, Stray KM, Wang T, Ray AS, Feng JY, Birkus G, Cihlar T, Hocek M.
J Med Chem (2011) 54 : 5498 -5507
PubMed 21711054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.00 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1814774 1 7.30
CHEMBL1814776 1 6.70
CHEMBL1814762 1 -
CHEMBL1814763 1 -
CHEMBL1814764 1 -
CHEMBL1814765 1 -
CHEMBL1814766 1 -
CHEMBL1814767 1 -
CHEMBL1814768 1 -
CHEMBL1814769 1 -
CHEMBL1814770 1 -
CHEMBL1814771 1 -
CHEMBL1814773 1 -
CHEMBL1814775 1 -
CHEMBL1814779 1 -
CHEMBL1814780 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1814774 IC50 = 50.0 nM 7.30
CHEMBL1814776 IC50 = 200.0 nM 6.70
CHEMBL1814762 IC50 > 5000.0 nM -
CHEMBL1814763 IC50 > 2000.0 nM -
CHEMBL1814764 IC50 > 10000.0 nM -
CHEMBL1814765 IC50 > 10000.0 nM -
CHEMBL1814766 IC50 > 5000.0 nM -
CHEMBL1814767 IC50 > 2000.0 nM -
CHEMBL1814768 IC50 > 5000.0 nM -
CHEMBL1814769 IC50 > 5000.0 nM -
CHEMBL1814770 IC50 > 5000.0 nM -
CHEMBL1814771 IC50 > 10000.0 nM -
CHEMBL1814773 IC50 > 5000.0 nM -
CHEMBL1814775 IC50 > 10000.0 nM -
CHEMBL1814779 IC50 > 10000.0 nM -
CHEMBL1814780 IC50 > 5000.0 nM -