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Assay Detail

CHEMBL1819642

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]citalopram from human recombinant SERT scintillation proximity assay
ChEMBL ↗
44
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sodium-dependent serotonin transporter (CHEMBL228) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors.
Micheli F, Cavanni P, Bettati M, Bonanomi G, Di Fabio R, Fazzolari E, Marchioro C, Roscic M, Tarsi L, Visentini F, Zonzini L, Worby A.
Bioorg Med Chem (2011) 19 : 3451 -3461
PubMed 21550808 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 44 8.82 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1818448 — — 1 10.00
CHEMBL608151 — — 1 9.80
CHEMBL296602 INDATRALINE 2.0 1 9.70
CHEMBL1818547 — — 1 9.70
CHEMBL1818455 — — 2 9.70
CHEMBL1818441 — — 1 9.60
CHEMBL1818451 — — 2 9.60
CHEMBL1818462 — — 1 9.60
CHEMBL1173607 — — 1 9.50
CHEMBL1818445 — — 2 9.40
CHEMBL1818454 — — 1 9.40
CHEMBL1818463 — — 1 9.40
CHEMBL1818444 — — 1 9.30
CHEMBL1818466 — — 1 9.30
CHEMBL1818465 — — 1 9.20
CHEMBL1173532 GSK1360707 1.0 1 9.20
CHEMBL1818545 — — 1 9.10
CHEMBL1818452 — — 2 9.10
CHEMBL1818453 — — 1 9.10
CHEMBL1818461 — — 1 9.10
CHEMBL1818460 — — 1 9.00
CHEMBL1818459 — — 1 9.00
CHEMBL1818546 — — 1 8.90
CHEMBL1818457 — — 1 8.70
CHEMBL1818456 — — 1 8.70
CHEMBL1818449 — — 1 8.70
CHEMBL1818468 — — 1 8.70
CHEMBL1818543 — — 2 8.70
CHEMBL1818464 — — 1 8.60
CHEMBL1818467 — — 1 8.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1818448 — Ki = 0.1 nM 10.00
CHEMBL608151 — Ki = 0.1585 nM 9.80
CHEMBL1818547 — Ki = 0.1995 nM 9.70
CHEMBL1818455 — Ki = 0.1995 nM 9.70
CHEMBL296602 INDATRALINE Ki = 0.1995 nM 9.70
CHEMBL1818441 — Ki = 0.2512 nM 9.60
CHEMBL1818462 — Ki = 0.2512 nM 9.60
CHEMBL1818451 — Ki = 0.2512 nM 9.60
CHEMBL1173607 — Ki = 0.3162 nM 9.50
CHEMBL1818445 — Ki = 0.3981 nM 9.40
CHEMBL1818463 — Ki = 0.3981 nM 9.40
CHEMBL1818454 — Ki = 0.3981 nM 9.40
CHEMBL1818444 — Ki = 0.5012 nM 9.30
CHEMBL1818466 — Ki = 0.5012 nM 9.30
CHEMBL1818465 — Ki = 0.631 nM 9.20
CHEMBL1173532 GSK1360707 Ki = 0.631 nM 9.20
CHEMBL1818452 — Ki = 0.7943 nM 9.10
CHEMBL1818453 — Ki = 0.7943 nM 9.10
CHEMBL1818461 — Ki = 0.7943 nM 9.10
CHEMBL1818545 — Ki = 0.7943 nM 9.10
CHEMBL1818459 — Ki = 1.0 nM 9.00
CHEMBL1818460 — Ki = 1.0 nM 9.00
CHEMBL1818546 — Ki = 1.259 nM 8.90
CHEMBL1818449 — Ki = 1.995 nM 8.70
CHEMBL1818456 — Ki = 1.995 nM 8.70
CHEMBL1818457 — Ki = 1.995 nM 8.70
CHEMBL1818468 — Ki = 1.995 nM 8.70
CHEMBL1818543 — Ki = 1.995 nM 8.70
CHEMBL1818467 — Ki = 2.512 nM 8.60
CHEMBL1818464 — Ki = 2.512 nM 8.60
CHEMBL1818542 — Ki = 3.162 nM 8.50
CHEMBL1818450 — Ki = 3.162 nM 8.50
CHEMBL1818469 — Ki = 3.981 nM 8.40
CHEMBL1818458 — Ki = 5.012 nM 8.30
CHEMBL1818443 — Ki = 6.31 nM 8.20
CHEMBL1818447 — Ki = 7.943 nM 8.10
CHEMBL1818446 — Ki = 7.943 nM 8.10
CHEMBL1818455 — Ki = 15.85 nM 7.80
CHEMBL1818445 — Ki = 15.85 nM 7.80
CHEMBL1818442 AMITIFADINE HYDROCHLORIDE Ki = 15.85 nM 7.80
CHEMBL1818452 — Ki = 19.95 nM 7.70
CHEMBL1818451 — Ki = 19.95 nM 7.70
CHEMBL1818543 — Ki = 39.81 nM 7.40
CHEMBL1818544 — Ki = 63.1 nM 7.20