Assay Detail
Binding
CHEMBL1825295
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Displacement of [3H]-N-methylspiperone from dopamine D2-like receptor in pig striatal tissue homogenates after 30 mins by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Striatum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.55 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.57 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 6.50 |
| CHEMBL1822916 | ECOPIPAM HYDROCHLORIDE | 3.0 | 1 | 5.70 |
| CHEMBL1467585 | — | — | 1 | 5.63 |
| CHEMBL1822918 | — | — | 1 | 5.07 |
| CHEMBL1822920 | — | — | 1 | 4.55 |
| CHEMBL1822919 | — | — | 1 | 4.35 |
| CHEMBL1822917 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 2.67 | nM | 8.57 |
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL1822916 | ECOPIPAM HYDROCHLORIDE | Ki | = | 2011.0 | nM | 5.70 |
| CHEMBL1467585 | — | Ki | = | 2364.0 | nM | 5.63 |
| CHEMBL1822918 | — | Ki | = | 8479.0 | nM | 5.07 |
| CHEMBL1822920 | — | Ki | = | 27980.0 | nM | 4.55 |
| CHEMBL1822919 | — | Ki | = | 44840.0 | nM | 4.35 |
| CHEMBL1822917 | — | Ki | = | 88000.0 | nM | 4.06 |