Compound Detail
CHEMBL1822916
ECOPIPAM HYDROCHLORIDE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL1822916 |
| Name | ECOPIPAM HYDROCHLORIDE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | APFMVAHRFWBCDG-JUOYHRLASA-N |
| Parent Compound | CHEMBL298406 |
| Active Moiety | CHEMBL298406 |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
4
Known Names
1
Indications
Molecular Properties
313.8
MW (Da)
3.98
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Tourette Syndrome
Activity Summary
Ki 2 meas. best 8.89
IC50 1 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 8.89 | 7.295 | 1.3 | 2 |
| D(1A) dopamine receptor CHEMBL2056 | IC50 | 8.82 | 8.82 | 1.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 1.3 | nM | 8.89 | Displacement of [3H]SCH23390 from dopamine D1-like receptor in pig striatal tiss... | 21862338 |
| D(1A) dopamine receptor | IC50 | = | 1.5 | nM | 8.82 | Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by c... | 32631525 |
| Unchecked | Ki | = | 2011.0 | nM | 5.7 | Displacement of [3H]-N-methylspiperone from dopamine D2-like receptor in pig str... | 21862338 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21862338 | 10.1016/j.bmc.2011.07.057 | Unchecked | 2 |
| 32631525 | 10.1016/j.bmcl.2020.127305 | D(1A) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine