Assay Detail
ADMET
CHEMBL1825987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazines: new variant of an old template and application to the discovery of anaplastic lymphoma kinase (ALK) inhibitors with in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.94 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1822515 | — | — | 1 | 5.03 |
| CHEMBL1821735 | — | — | 1 | 4.84 |
| CHEMBL1822525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1822515 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1821735 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL1822525 | — | IC50 | > | 12000.0 | nM | - |